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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Suínos e Aves. |
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Data corrente: |
22/08/2022 |
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Data da última atualização: |
22/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NICIURA, S. C. M.; BENAVIDES, M. V.; OKINO, C. H.; IBELLI, A. M. G.; MINHO, A. P.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
SIMONE CRISTINA MEO NICIURA, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; CINTIA HIROMI OKINO, CPPSE; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; ALESSANDRO PELEGRINE MINHO, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Genome-wide association study for Haemonchus contortus resistance in Morada Nova sheep. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Pathogens, v. 11, n. 8, aug. 2022, 939. |
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Páginas: |
12 p. |
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DOI: |
https://doi.org/10.3390/pathogens11080939 |
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Idioma: |
Inglês |
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Conteúdo: |
Among the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for animal identification. MenosAmong the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for... Mostrar Tudo |
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Palavras-Chave: |
Gastrointestinal nematode control; GWAS; Molecular markers; Ovine; Parasite resistance. |
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Thesagro: |
Marcador Molecular; Ovino; Parasito. |
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Thesaurus Nal: |
Genotyping. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145606/1/GenomeWideAssociation.pdf
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Marc: |
LEADER 02449naa a2200325 a 4500
001 2145606
005 2022-08-22
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/pathogens11080939$2DOI
100 1 $aNICIURA, S. C. M.
245 $aGenome-wide association study for Haemonchus contortus resistance in Morada Nova sheep.$h[electronic resource]
260 $c2022
300 $a12 p.
520 $aAmong the gastrointestinal nematodes affecting sheep, Haemonchus contortus is the most prevalent and virulent, resulting in health problems and production losses. Therefore, selecting sheep resistant to H. contortus is a suitable and sustainable strategy for controlling endoparasites in flocks. Here, 287 lambs of the native Brazilian Morada Nova hair sheep breed were subjected to two consecutive artificial infections with H. contortus and assessed for fecal egg count (FEC), packed cell volume (PCV), and live weight (LW). Forty-four animals ranked as having extreme resistance phenotypes were genotyped using the Illumina OvineSNP50v3 chip. A case?control genome-wide association study (GWAS) detected 37 significant (p < 0.001) markers in 12 ovine chromosomes in regions harboring quantitative trait loci (QTL) for FEC, Trichostrongylus spp. adults and larvae, weight, and fat; and candidate genes for immune responses, mucins, hematological parameters, homeostasis, and growth. Four single-nucleotide polymorphisms (SNP; OAR1_rs427671974, AR2_rs419988472, OAR5_rs424070217, and OAR17_rs401006318) genotyped by qPCR followed by high-resolution melting (HRM) were associated with FEC and LW. Therefore, molecular markers detected by GWAS for H. contortus resistance in Morada Nova sheep may support animal selection programs aimed at controlling gastrointestinal nematode infections in flocks. Furthermore, genotyping of candidate genes using HRM qPCR may provide a rapid and efficient tool for animal identification.
650 $aGenotyping
650 $aMarcador Molecular
650 $aOvino
650 $aParasito
653 $aGastrointestinal nematode control
653 $aGWAS
653 $aMolecular markers
653 $aOvine
653 $aParasite resistance
700 1 $aBENAVIDES, M. V.
700 1 $aOKINO, C. H.
700 1 $aIBELLI, A. M. G.
700 1 $aMINHO, A. P.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tPathogens$gv. 11, n. 8, aug. 2022, 939.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
30/10/1996 |
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Data da última atualização: |
21/06/2018 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
OLIVEIRA, E. R. de; JOHNSON, W. L. |
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Afiliação: |
Ederlon Ribeiro de Oliveira, CNPC; Willian L. Johnson, North Caroline State University, Raleigh (USA). |
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Título: |
Present and improved production systems for meat goats in Northeast Brasil. |
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Ano de publicação: |
1989 |
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Fonte/Imprenta: |
In: JOHNSON, W. L.; OLIVEIRA, E. R. de (Ed.). Improving meat goat production in the semiarid tropics. Sobral: EMBRAPA-CNPC; Davis: University of California, Small Ruminant Collaborative Research Support Program, SR-CRSP, 1989. p. 20-32. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Goat production in the semiarid tropics of Northeast Brazil, as well as in other semiarid developing regions, is characterized by its extensive management and low offtake. The caracterization of the semiarid rangeland of the area and a socioeconomic profile of the goats producers are presented in chapters 1 and 2. In this champter we give a general overview of land organization in Northeast Brazil, including the major crops and animal species utilized, and of the important of goats within this integrated production system. Finally we describe the actual status of goat keeping in this region, and where possible, we compare some results, obtained under experimental conditions with data from producers' herds. |
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Palavras-Chave: |
Brasil; Caprino de corte; Nordeste; Northeast; Production system. |
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Thesagro: |
Caprino; Carne; Sistema de produção; Sociologia Rural. |
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Thesaurus NAL: |
Brazil; Goats; Meat production. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01631naa a2200277 a 4500
001 1514605
005 2018-06-21
008 1989 bl uuuu u00u1 u #d
100 1 $aOLIVEIRA, E. R. de
245 $aPresent and improved production systems for meat goats in Northeast Brasil.
260 $c1989
520 $aAbstract: Goat production in the semiarid tropics of Northeast Brazil, as well as in other semiarid developing regions, is characterized by its extensive management and low offtake. The caracterization of the semiarid rangeland of the area and a socioeconomic profile of the goats producers are presented in chapters 1 and 2. In this champter we give a general overview of land organization in Northeast Brazil, including the major crops and animal species utilized, and of the important of goats within this integrated production system. Finally we describe the actual status of goat keeping in this region, and where possible, we compare some results, obtained under experimental conditions with data from producers' herds.
650 $aBrazil
650 $aGoats
650 $aMeat production
650 $aCaprino
650 $aCarne
650 $aSistema de produção
650 $aSociologia Rural
653 $aBrasil
653 $aCaprino de corte
653 $aNordeste
653 $aNortheast
653 $aProduction system
700 1 $aJOHNSON, W. L.
773 $tIn: JOHNSON, W. L.; OLIVEIRA, E. R. de (Ed.). Improving meat goat production in the semiarid tropics. Sobral: EMBRAPA-CNPC; Davis: University of California, Small Ruminant Collaborative Research Support Program, SR-CRSP, 1989. p. 20-32.
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Embrapa Caprinos e Ovinos (CNPC) |
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